Characterization of urethra closure in female neonatal mice at histological and molecular levels.

ABSTRACT:

In brief

Female hypospadias is a little-known and poorly studied birth defect. This research establishes an anatomical and molecular foundation for future research to investigate the origins of this defect.

Abstract

Hypospadias is a congenital anomaly of the external genitalia where the urethra does not properly close. In humans, hypospadias is mostly reported in male newborns, whereas in females hypospadias is rare, although it is generally considered to be under-reported. Improper urethra closure in the female genitalia can cause recurrent genitourinary tract infections and infertility. In mice, female hypospadias was induced by exposure to exogenous estrogenic compounds. Aside from the link between estrogen exposure and female hypospadias, the process of female urethra cl

SUBMITTER: Kitakule AS 

PROVIDER: S-EPMC11427134 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature