Piezo1 ion channels are capable of conformational signaling.

ABSTRACT: Piezo1 is a mechanically activated ion channel that senses forces with short latency and high sensitivity. Piezos undergo large conformational changes, induce far-reaching deformation onto the membrane, and modulate the function of two-pore potassium (K_2P) channels. Taken together, this led us to hypothesize that Piezos may be able to signal their conformational state to other nearby proteins. Here, we use chemical control to acutely restrict Piezo1 conformational flexibility and show that Piezo1 conformational changes, but not ion permeation through them, are required for modulating the K_2P channel K_2P2.1 (TREK1). Super-resolution imaging and stochastic simulations further reveal that both channels do not co-localize, which implies that modulation is not m

SUBMITTER: Lewis AH 

PROVIDER: S-EPMC11427155 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature