Causal associations between constipation and pan-cancer: a bidirectional Mendelian randomization study.

ABSTRACT:

Objective

Observational studies have suggested a potential association between constipation and several cancers. However, the causal relationship between constipation and cancer remains unclear. The purpose of this study is to explore the potential causal relationship between constipation and pan-cancer using Mendelian Randomization (MR) methods.

Methods

We performed a bidirectional MR analysis using publicly available summary data from Genome-Wide Association Studies (GWAS) statistics. The Inverse Variance Weighted (IVW) method was used as the main analysis method. We also used four MR methods: MR-Egger, Weighted Median, MR-PRESSO and MR.RAPS. Simultaneously, MR-Egger regression, Cochran's Q test and MR-PRESSO Global test were used to estimate the pleiotropy and heterogenei

SUBMITTER: Dang Y 

PROVIDER: S-EPMC11427234 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature