Effects of thyroid hormones modify the association between pre-pregnancy obesity and GDM: evidence from a mediation analysis.

ABSTRACT:

Objective

Conflicting associations have been noted between thyroid function and gestational diabetes mellitus (GDM), with indications that pre-pregnancy BMI might influence these relationships. This study aims to examine the effect of thyroid hormone indices and their mediation role on the risk of GDM.

Methods

Pregnant women in our study were recruited from the Zhoushan Pregnant Women Cohort, Zhejiang Province, China. Participants who had their first prenatal follow-up and measured thyroid biomarkers in the first trimester, and oral glucose tolerance test (OGTT) records in the second trimester were eligible for inclusion in this study. The data were extracted from the Electronic Medical Record System database, at Zhoushan Maternal and Child Care Hospital. Maternal informatio

SUBMITTER: Alifu X 

PROVIDER: S-EPMC11427249 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature