Causal roles of circulating cytokines in sarcopenia-related traits: a Mendelian randomization study.

ABSTRACT:

Background

Epidemiological and experimental evidence suggests that chronic inflammation plays an important role in the onset and progression of sarcopenia. However, there is inconsistent data on the inflammatory cytokines involved in the pathogenesis of sarcopenia. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between circulating cytokines and sarcopenia-related traits.

Methods

The MR analysis utilized genetic data from genome-wide association study that included genetic variations in 41 circulating cytokines and genetic variant data for appendicular lean mass (ALM), hand grip strength, and usual walking pace. Causal associations were primarily explored using the inverse variance-weighted (IVW) method, supplemen

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11427268 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature