Causal role of immune cells in diabetic nephropathy: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Diabetic nephropathy (DN) stands as a pervasive chronic renal disease worldwide, emerging as the leading cause of renal failure in end-stage renal disease. Our objective is to pinpoint potential immune biomarkers and evaluate the causal effects of prospective therapeutic targets in the context of DN.

Methods

We employed Mendelian randomization (MR) analysis to examine the causal associations between 731 immune cell signatures and the risk of DN. Various analytical methods, including inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode, were employed for the analysis. The primary analytical approach utilized was the inverse-variance weighted (IVW) method. To ensure the reliability of our findings, we conducted comprehensive sen

SUBMITTER: Wang SY 

PROVIDER: S-EPMC11427287 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature