Oral microbiome diversity shapes the association between sleep duration and depression.

ABSTRACT:

Background

Emerging research suggests the relationship between the oral microbiome and sleep duration with depression, however, the precise mechanisms by which oral microbial diversity influences the sleep-depression nexus remain to be elucidated.

Methods

We analyzed data from 4,692 participants in the National Health and Nutrition Examination Survey (NHANES), incorporating key demographic variables, oral microbiome diversity metrics, sleep duration, and depression assessment variables. Classical multidimensional scaling facilitated dimensionality reduction, while unsupervised clustering divided participants into groups based on β-diversity dissimilarity matrices. We examined the moderating effects of oral microbiome diversity on the sleep-depression relationship by incorpor

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11427320 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature