Effects of obesogenic diet and 17β-estradiol in female mice with <i>APOE</i> 3/3, 3/4, and 4/4 genotypes.

ABSTRACT: The main genetic risk factor for Alzheimer's disease (AD) is the apolipoprotein E ε4 allele (APOE4). AD risk associated with APOE4 disproportionately affects women. Furthermore, human and rodent studies indicate that the cognitive deficits associated with APOE4 are greater in females. One modifiable AD risk factor is obesity during middle age. Given that approximately two-thirds of US adults are overweight, it is important to understand how obesity affects AD risk, how it interacts with APOE4, and the extent to which its detrimental effects can be mitigated with therapeutics. One intervention study for women is estrogen-based hormone therapy, which can exert numerous health benefits when administered in early middle age. No experimental studies have examined the

SUBMITTER: Christensen A 

PROVIDER: S-EPMC11427389 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature