Endogenous orexin and hyperacute autonomic responses after resuscitation in a preclinical model of cardiac arrest.

ABSTRACT:

Objectives

The study of autonomic responses to cardiac arrest (CA) resuscitation deserves attention due to the impact of autonomic function on survival and arousal. Orexins are known to modulate autonomic function, but the role of endogenous orexin in hyperacute recovery of autonomic function post-resuscitation is not well understood. We hypothesized that endogenous orexin facilitates hyperacute cardiovascular sympathetic activity post-resuscitation, and this response could be attenuated by suvorexant, a dual orexin receptor antagonist.

Methods

A well-established 7-min asphyxial CA rat model was studied. Heart rate (HR) and blood pressure were monitored from baseline to 90-min post-resuscitation. Autonomic function was evaluated by spectral analysis of HR variability, whereb

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11427410 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature