A causal association between esophageal cancer and the oral microbiome: a Mendelian randomization study based on an Asian population.

ABSTRACT:

Background

Previous studies have suggested a crosstalk between the oral microbiome and esophageal cancer (EC), but the exact relationship is unclear. This study aimed to investigate the causal relationship between changes in the oral microbiome and EC by Mendelian randomization (MR).

Materials and methods

In the study, bidirectional MR analyses were conducted using genome-wide association study data from the oral microbiomes from the 4D-SZ cohort and EC data from the BioBank Japan cohort. Multiple sensitivity tests, including Cochrane's Q statistic, MR-Egger intercept, and MR-PRESSO, were used to assess and validate the relative stability of the resulting data at various levels.

Results

Among the 3,117 samples studied, 73 oral microbiomes were found to be statisticall

SUBMITTER: Hu K 

PROVIDER: S-EPMC11427439 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature