Immunosuppression regimen and latitude impact keratinocyte carcinoma risk in U.S. liver transplant recipients.

ABSTRACT: Immunosuppression after solid organ transplantation is associated with an increased risk of keratinocyte carcinoma (KC). Despite its established morbidity, KC risk in liver transplant (LT) recipients is understudied, including the contribution of immunosuppression regimen and latitude. A retrospective cohort of 9,966 adult first LT alone recipients alive with their native allograft at 1-year post-LT without prior KC between 2007 and 2016 were identified using linked data from the Organ Procurement and Transplantation Network and Medicare administrative claims. The primary exposures were immunosuppression regimen and latitude of residence. The primary outcome was incident, de novo KC occurring at least 1-year after LT. Adjusted Cox regression analysis stratified by transplant center was use

SUBMITTER: Rosenthal BE 

PROVIDER: S-EPMC11427564 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature