High-resolution ion mobility based on traveling wave structures for lossless ion manipulation resolves hidden lipid features.

ABSTRACT: High-resolution ion mobility (resolving power > 200) coupled with mass spectrometry (MS) is a powerful analytical tool for resolving isobars and isomers in complex samples. High-resolution ion mobility is capable of discerning additional structurally distinct features, which are not observed with conventional resolving power ion mobility (IM, resolving power ~ 50) techniques such as traveling wave IM and drift tube ion mobility (DTIM). DTIM in particular is considered to be the "gold standard" IM technique since collision cross section (CCS) values are directly obtained through a first-principles relationship, whereas traveling wave IM techniques require an additional calibration strategy to determine accurate CCS values. In this study, we aim to evaluate the separation capabilities of a t

SUBMITTER: Reardon AR 

PROVIDER: S-EPMC11427608 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature