Accuracy of holmium-166 SPECT/CT quantification over a large range of activities.

ABSTRACT:

Background

Quantitative imaging is a crucial step for dosimetry in radionuclide therapies. Traditionally, SPECT/CT imaging is quantified based on scanner-specific conversion factors or self-calibration, but recently absolute quantification methods have been introduced in commercial SPECT reconstruction software (Broad Quantification, Siemens Healthineers). In this phantom study we investigate the accuracy of three quantification methods for holmium-166 SPECT/CT imaging, and provide recommendations for clinical dosimetry.

Methods

One cylindrical phantom, filled with a homogeneous holmium-166-chloride activity concentration solution, was imaged at one time point to determine a scanner-specific conversion factor, and to characterize the spatial dependency of the activity concen

SUBMITTER: Westlund Gotby LEL 

PROVIDER: S-EPMC11427639 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature