Rectum necrosis in a patient with severe COVID19 infection after CAR-T therapy: a case report.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID19) can cause gastrointestinal complications as well as respiratory tract disease. Coagulation abnormalities and thrombosis frequently occur in COVID19, especially in cases with severe clinical outcome. The relationship between gastrointestinal perforation and coagulopathy due to COVID19 remains unclear.

Case presentation

A 49-year-old female received Chimeric antigen receptor T (CAR-T) therapy for an early recurrence of diffuse large B-cell lymphoma (DLBCL) that was refractory to chemotherapy. She was diagnosed with cytokine release syndrome (CRS) because of a fever and oxygen desaturation, and administered tocilizumab. Forty days after completing CAR-T therapy, she was infected with COVID19 and transferred to our hospital. Her gene

SUBMITTER: Saeki K 

PROVIDER: S-EPMC11427651 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature