Tumor specimen cold ischemia time impacts molecular cancer drug target discovery.

ABSTRACT: Tumor tissue collections are used to uncover pathways associated with disease outcomes that can also serve as targets for cancer treatment, ideally by comparing the molecular properties of cancer tissues to matching normal tissues. The quality of such collections determines the value of the data and information generated from their analyses including expression and modifications of nucleic acids and proteins. These biomolecules are dysregulated upon ischemia and decompose once the living cells start to decay into inanimate matter. Therefore, ischemia time before final tissue preservation is the most important determinant of the quality of a tissue collection. Here we show the impact of ischemia time on tumor and matching adjacent normal tissue samples for mRNAs in 1664, proteins in 1818, a

SUBMITTER: von der Heyde S 

PROVIDER: S-EPMC11427669 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature