Elevated Proportions of Circulating CXCR5⁺ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma.

ABSTRACT:

Materials and methods

Using flow cytometry, we identified and quantified Group 2 innate lymphocytes, T helper 2 cells, follicular helper T cells, and T helper 17 cells in peripheral blood samples from 49 individuals with asthma. We then conducted cross-sectional analyses to assess relationships between levels of these immune cells and lung function parameters, including the percentage predicted forced expiratory volume in 1 s (%FEV1). We also examined correlations between the proportions of immune cells and type 2 biomarkers.

Results

Proportions of CXCR5⁺ follicular helper T cells in human peripheral blood, as opposed to Group 2 innate lymphoid cells (ILC2) or T helper 2 cells, were significantly higher in cases with %FEV1 < 80% compared to those with %FEV1 ≥ 80%.

SUBMITTER: Tsukuda TK 

PROVIDER: S-EPMC11427719 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature