The causal association between epilepsy and amyotrophic lateral sclerosis: A two-sample Mendelian randomization study.

ABSTRACT:

Objectives

Epilepsy and amyotrophic lateral sclerosis (ALS) are common neurological disorders. The association between the two disorders has been raised in observational studies. However, it is uncertain to what extent they have mutual causal effects. In this study, we aimed to investigate their causal association using a two-sample Mendelian randomization (MR) method.

Methods

We performed a two-sample bidirectional MR analysis to evaluate the causal association of epilepsy with the risk of ALS. Publicly published genome-wide association study statistics for epilepsy and ALS were used in the study. The primary analysis included genetic variants with a p value of less than 1 × 10^-5 as instrumental variables. We applied several alternative methods, including inverse

SUBMITTER: Cui Y 

PROVIDER: S-EPMC11427789 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature