Transformation of a low-grade glioma into a glioblastoma along with the development of lung and mediastinal lymph node metastases after repeated craniotomy: A case report.

ABSTRACT: Extracranial metastasis of glioma is extremely rare. Herein, we report a case of glioblastoma that originated and showed stepwise malignant transformation from a low-grade glioma (LGG) along with the presence of lung and mediastinal lymph node metastases after repeated craniotomy. A 30-year-old man presented with hemoptysis. Thoracic computed tomography revealed a space-occupying lesion in the right upper lung with mediastinal nodal and metastases in both lungs; lung cancer was suspected. The patient's medical history showed that he had undergone craniotomy three times in 7 years for a primary LGG disease relapse, and stepwise malignant-transformed high-grade glioma (HGG). However, brain magnetic resonance imaging did not reveal any relapse of intracranial tumors. The diagnosis of extracra

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11427796 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature