The impact of hospital-specific guidelines on carbapenem use and patient outcomes in a setting for high endemicity with multidrug-resistant gram-negative bacilli.

ABSTRACT:

Objective

This study aims to assess the impact of hospital-specific guidelines on the optimal utilization of carbapenems and to examine their effects on patient outcomes.

Design

Quasi-experimental study.

Setting

Tertiary care hospital in Turkey where infectious diseases (IDs) consultation and antibiotic approval are mandatory for carbapenem use.

Participants

All inpatients ≥18 years of age who received a carbapenem for at least 24 hours during the study periods were enrolled.

Intervention

Hospital-specific treatment guidelines were introduced in April 2019. The control group was the year 2018, when there were no guidelines (pre-GP). The year 2020 was analyzed as the intervention period (post-GP).

Results

A total of 678 patients were analyzed, 326

SUBMITTER: Bosnak C 

PROVIDER: S-EPMC11428004 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature