METTL23 Variants and Patients With Normal-Tension Glaucoma.

ABSTRACT:

Importance

This research confirms and further establishes that pathogenic variants in a fourth gene, METTL23, are associated with autosomal dominant normal-tension glaucoma (NTG).

Objective

To determine the frequency of glaucoma-causing pathogenic variants in the METTL23 gene in a cohort of patients with NTG from Iowa.

Design, setting, and participants

This case-control study took place at a single tertiary care center in Iowa from January 1997 to January 2024, with analysis occurring between January 2023 and January 2024. Two groups of participants were enrolled from the University of Iowa clinics: 331 patients with NTG and 362 control individuals without glaucoma. Patients with a history of trauma; steroid use; stigmata of pigment dispersion syndrome; exfoliation sy

SUBMITTER: Scheetz TE 

PROVIDER: S-EPMC11428026 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature