Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer.

ABSTRACT:

Importance

The oral microbiota may be involved in development of head and neck squamous cell cancer (HNSCC), yet current evidence is largely limited to bacterial 16S amplicon sequencing or small retrospective case-control studies.

Objective

To test whether oral bacterial and fungal microbiomes are associated with subsequent risk of HNSCC development.

Design, setting, and participants

Prospective nested case-control study among participants providing oral samples in 3 epidemiological cohorts, the American Cancer Society Cancer Prevention Study II Nutrition Cohort, the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, and the Southern Community Cohort Study. Two hundred thirty-six patients who prospectively developed HNSCC were identified during a mean (SD

SUBMITTER: Kwak S 

PROVIDER: S-EPMC11428028 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature