Integrin α6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151.

ABSTRACT: Heterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation of pre-metastatic "niches" in draining lymph nodes (LNs) to promote lymphatic metastasis. In order to identify the specific subpopulations of EVs involved, we performed high-resolution proteomic analysis combined with nanoflow cytometry of bladder cancer (BCa) tissue-derived EVs to identify a novel subset of tumour-derived EVs that contain integrin α6 (ITGA6⁺EVs) and revealed the positive correlation of ITGA6⁺EVs with the formation of pre-metastatic niche in draining LNs and lymphatic metastasis in multicentre clinical analysis of 820-case BCa patients. BCa-derived ITGA6⁺EVs induced E-selectin (SELE)-marked lymphatic remodelling pre-metastati

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11428163 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature