Risk Factors Associated with Antibiotic Exposure Variability in Critically Ill Patients: A Systematic Review.

ABSTRACT: (1) Background: Knowledge about the behavior of antibiotics in critically ill patients has been increasing in recent years. Some studies have concluded that a high percentage may be outside the therapeutic range. The most likely cause of this is the pharmacokinetic variability of critically ill patients, but it is not clear which factors have the greatest impact. The aim of this systematic review is to identify risk factors among critically ill patients that may exhibit significant pharmacokinetic alterations, compromising treatment efficacy and safety. (2) Methods: The search included the PubMed, Web of Science, and Embase databases. (3) Results: We identified 246 observational studies and ten clinical trials. The most studied risk factors in the literature were renal function, weight, ag

SUBMITTER: Gras-Martin L 

PROVIDER: S-EPMC11428266 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature