A Multiplexed Quantitative Proteomics Approach to the Human Plasma Protein Signature.

ABSTRACT: Despite the plasma proteome being able to provide a unique insight into the health and disease status of individuals, holding singular promise as a source of protein biomarkers that could be pivotal in the context of personalized medicine, only around 100 proteins covering a few human conditions have been approved as biomarkers by the US Food and Drug Administration (FDA) so far. Mass spectrometry (MS) currently has enormous potential for high-throughput analysis in clinical research; however, plasma proteomics remains challenging mainly due to the wide dynamic range of plasma protein abundances and the time-consuming procedures required. We applied a new MS-based multiplexed proteomics workflow to quantitate proteins, encompassing 67 FDA-approved biomarkers, in >1300 human plasma samples

SUBMITTER: Nunez E 

PROVIDER: S-EPMC11428418 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature