Distinct connectivity patterns in bipolar and unipolar depression: a functional connectivity multivariate pattern analysis study.

ABSTRACT:

Background

Patients with bipolar disorder (BD) and major depressive disorder (MDD) exhibit depressive episodes with similar symptoms despite having different and poorly understood underlying neurobiology, often leading to misdiagnosis and improper treatment. This exploratory study examined whole-brain functional connectivity (FC) using FC multivariate pattern analysis (fc-MVPA) to identify the FC patterns with the greatest ability to distinguish between currently depressed patients with BD type I (BD I) and those with MDD.

Methodology

In a cross-sectional design, 41 BD I, 40 MDD patients and 63 control participants completed resting state functional magnetic resonance imaging scans. Data-driven fc-MVPA, as implemented in the CONN toolbox, was used to identify clusters with d

SUBMITTER: Pastrnak M 

PROVIDER: S-EPMC11428473 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature