Mendelian randomization analyses explore the effects of micronutrients on different kidney diseases.

ABSTRACT:

Background

The impact of micronutrients, including vitamins and minerals, on different kidney diseases has been reported in some observational studies; however, their causal relationship remains uncertain. We aimed to ascertain the causal genetic relationships between micronutrients and different kidney diseases using the Mendelian randomization (MR) method.

Methods

Instrumental variables (IVs) for genetically predicting calcium (Ca), iron (Ir), Zinc (Zn), selenium (Se), copper (Cu), vitamin D (Vit D), and vitamin C (Vit C) levels in humans were obtained, and a bidirectional two-sample MR was used to examine potential associations between the levels of these seven micronutrients and the risk of seven different kidney diseases including hypertensive renal disease, diabetic ne

SUBMITTER: Shi C 

PROVIDER: S-EPMC11428537 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature