The Natural HASPIN Inhibitor Coumestrol Suppresses Intestinal Polyp Development, Cachexia, and Hypogonadism in a Mouse Model of Familial Adenomatous Polyposis (Apc^Min/+).

ABSTRACT: (1) Background: HASPIN kinase is involved in regulating spindle function and chromosome segregation, as well as phosphorylating histone H3 at Thr3 in mitotic cells. Several HASPIN inhibitors suppress cancer cell proliferation. It was recently reported that coumestrol from bean sprouts inhibits HASPIN, and a cultivation method for bean sprouts containing large amounts of coumestrol has been established. Here, we showed the effects of bean sprout ingestion on intestinal polyp development, cachexia, and hypogonadism in a mouse model of familial adenomatous polyposis (Apc^Min/+). (2) Methods: Apc^Min/+ mice were randomized into control and treatment groups. Mice in the control group were given the standard diet, while those in the treatment group were given th

SUBMITTER: Tanaka H 

PROVIDER: S-EPMC11428679 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature