Neuropathological mRNA Expression Changes after Single Mild Traumatic Brain Injury in Pigs.

ABSTRACT: Traumatic brain injury (TBI) is a public health concern, with an estimated 42 million cases globally every year. The majority of TBIs are mild TBIs, also known as concussion, and result from the application of mechanical forces on the head. Most patients make a complete recovery and mortality is rare; therefore, studies investigating cellular changes after mild TBI in a clinical setting are limited. To address this constraint, our group utilized a pig model of closed-head rotational acceleration-induced TBI, which recreated the biomechanical loading parameters associated with concussion on a large gyrencephalic brain similar to humans. While our previous research has focused on immunohistochemical characterization of neuropathology, the current study utilized transcriptomic assays to evalu

SUBMITTER: Grovola MR 

PROVIDER: S-EPMC11428889 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature