Transmission network of Hepatitis C virus subtype 2a in Huazhou County, Shaanxi Province, China.

ABSTRACT:

Background

Huazhou County has one of the highest rates of hepatitis C virus (HCV) infection incidence and prevalence in Shaanxi Province, northwest China. Understanding the characteristics of HCV transmission patterns in this area could help guide targeted prevention strategies. This study employed phylogenetic analysis and the construction of a molecular transmission network of HCV-infected people in Huazhou County to describe the predominant strains of HCV and identify factors associated with onward transmission.

Methods

Whole blood samples were obtained from HCV RNA-positive individuals for sequencing of the non-structural protein 5B region. A maximum-likelihood (ML) phylogenetic tree was constructed to determine HCV subgenotypes, and Bayesian phylogenetic analysis was em

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11428910 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature