Investigating Modifiable Risk Factors Across Dementia Subtypes: Insights from the UK Biobank.

ABSTRACT: This study investigates the relationship between modifiable risk factors and dementia subtypes using data from 460,799 participants in the UK Biobank. Utilizing univariate Cox proportional hazards regression models, we examined the associations between 83 modifiable risk factors and the risks of all-cause dementia (ACD), Alzheimer's disease (AD), and vascular dementia (VD). Composite scores for different domains were generated by aggregating risk factors associated with ACD, AD, and VD, respectively, and their joint associations were assessed in multivariable Cox models. Additionally, population attributable fractions (PAF) were utilized to estimate the potential impact of eliminating adverse characteristics of the risk domains. Our findings revealed that an unfavorable medical history sig

SUBMITTER: Ma X 

PROVIDER: S-EPMC11428917 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature