Topological structural characteristics in patients with systemic lupus erythematosus with and without neuropsychiatric symptoms.

ABSTRACT:

Purpose

This study investigated the topological structural characteristics of systemic lupus erythematosus (SLE) with and without neuropsychiatric symptoms (NPSLE and non-NPSLE), and explore their clinical implications.

Methods

We prospectively recruited 50 patients with SLE (21 non-NPSLE and 29 NPSLE) and 32 age-matched healthy controls (HCs), using MRI diffusion tensor imaging. Individual structural networks were constructed using fibre numbers between brain areas as edge weights. Global metrics (eg, small-worldness, global efficiency) and local network properties (eg, degree centrality, nodal efficiency) were computed. Group comparisons of network characteristics were conducted. Clinical correlations were assessed using partial correlation, and differentiation between non

SUBMITTER: Ao F 

PROVIDER: S-EPMC11429004 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature