Impaired Upper Airway Muscle Function with Excessive or Deficient Dietary Intake of Selenium in Rats.

ABSTRACT: Obstructive sleep apnoea (OSA) involves impaired upper airway muscle function and is linked to several pathologies including systemic hypertension, daytime somnolence and cognitive decline. Selenium is an essential micronutrient that exerts many of its effects through selenoproteins. Evidence indicates that either deficient or excessive dietary selenium intake can result in impaired muscle function, termed nutritional myopathy. To investigate the effects of selenium on an upper airway muscle, the sternohyoid, rats were fed on diets containing deficient, normal (0.5 ppm sodium selenite) or excessive (5 ppm selenite) selenium for a period of two weeks. Sternohyoid contractile function was assessed ex vivo. Serum selenium levels and activity of the glutathione antioxidant system were determin

SUBMITTER: Burns DP 

PROVIDER: S-EPMC11429047 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature