Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers.

ABSTRACT:

Background

Alterations in DNA methylation (DNAm) have been observed in patients with fatty liver, but whether they are cause or consequence remains unknown. The study aimed to investigate longitudinal association of epigenome-wide DNAm with liver fat content (LFC) in Chinese participants, and explore their temporal relationships.

Methods

Data were obtained from 2 waves over a four-year time period of the Shanghai Changfeng Study (discovery, n = 407 and replication, n = 126). LFC and peripheral blood DNAm were repeatedly measured using quantitative hepatic ultrasonography and the 850 K Illumina EPIC BeadChip, respectively. Longitudinal and cross-sectional epigenome-wide association studies (EWASs) were conducted with linear mixed model and linear regression model, respectivel

SUBMITTER: Zeng H 

PROVIDER: S-EPMC11429307 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature