Influence of vitamin D supplementation on muscle strength and exercise capacity in South African schoolchildren: secondary outcomes from a randomised controlled trial (ViDiKids).

ABSTRACT:

Objective

To determine whether vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness and risk of exercise-induced bronchoconstriction (EIB) in South African schoolchildren.

Methods

Substudy (n=450) in Cape Town schoolchildren aged 8-11 years nested within a phase 3 randomised placebo-controlled trial (ViDiKids). The intervention was weekly oral doses of 10 000 IU vitamin D₃ (n=228) or placebo (n=222) for 3 years. Outcome measures were serum 25-hydroxyvitamin D₃ (25(OH)D₃) concentrations, grip strength, standing long jump distance, peak oxygen uptake (VO_2peak, determined using 20 m multistage shuttle run tests) and the proportion of children with EIB, measured at end-study.

Results

SUBMITTER: Middelkoop K 

PROVIDER: S-EPMC11429360 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature