Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancers.

ABSTRACT: Therapeutics targeting tumor endothelial cells (TECs) have been explored for decades, with only suboptimal efficacy achieved, partly due to an insufficient understanding of the TEC heterogeneity across cancer patients. We integrated single-cell RNA-seq data of 575 cancer patients from 19 solid tumor types, comprehensively charting the TEC phenotypic diversities. Our analyses uncovered underappreciated compositional and functional heterogeneity in TECs from a pan-cancer perspective. Two subsets, CXCR4 ⁺ tip cells and SELE ⁺ veins, represented the prominent angiogenic and proinflammatory phenotypes of TECs, respectively. They exhibited distinct spatial organization patterns, and compared to adjacent non-tumor tissues, tumor tissue showed an increased preva

SUBMITTER: Li J 

PROVIDER: S-EPMC11429526 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature