Metabolomic Profiling of Pulmonary Neuroendocrine Neoplasms.

ABSTRACT:

Background/objectives

Pulmonary neuroendocrine neoplasms (NENs) account for 20% of malignant lung tumors. Their management is challenging due to their diverse clinical features and aggressive nature. Currently, metabolomics offers a range of potential cancer biomarkers for diagnosis, monitoring tumor progression, and assessing therapeutic response. However, a specific metabolomic profile for early diagnosis of lung NENs has yet to be identified. This study aims to identify specific metabolomic profiles that can serve as biomarkers for early diagnosis of lung NENs.

Methods

We measured 153 metabolites using liquid chromatography combined with mass spectrometry (LC-MS) in the plasma of 120 NEN patients and compared them with those of 71 healthy individuals. Additionally, we com

SUBMITTER: Boullier C 

PROVIDER: S-EPMC11429548 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature