Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer.

ABSTRACT: The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment. While immunotherapies have shown efficacy in various cancers, including breast cancer, patient responses vary widely. Some patients receive significant benefits, while others experience minimal or no improvement. This disparity underscores the complexity and diversity of the immune system. In this study, we investigated the immune landscape and cell-cell communication within the TME of breast cancer through integrated analysis of bulk and single-cell RNA sequencing data. We established profiles of tumor immune infiltration that span across a broad spectrum of adaptive and innate immune cells. Our clustering analysi

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11429566 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature