Tissue-specific metabolomic signatures for a <i>doublesex</i> model of reduced sexual dimorphism.

ABSTRACT: Sex has a major effect on the metabolome. However, we do not yet understand the degree to which these quantitative sex differences in metabolism are associated with anatomical dimorphism and modulated by sex-specific tissues. In the fruit fly, Drosophila melanogaster, knocking out the doublesex (dsx) gene gives rise to adults with intermediate sex characteristics. Here we sought to determine the degree to which this key node in sexual development leads to sex differences in the fly metabolome. We measured 91 metabolites across head, thorax and abdomen in Drosophila, comparing the differences between distinctly sex-dimorphic flies with those of reduced sexual dimorphism: dsx null flies. Notably, in the reduced dimorphism flies, we observed a sex difference

SUBMITTER: Coig R 

PROVIDER: S-EPMC11429604 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature