A Generalized <i>Adder</i> mechanism for Cell Size Homeostasis: Implications for Stochastic Dynamics of Clonal Proliferation.

ABSTRACT: Measurements of cell size dynamics have revealed phenomenological principles by which individual cells control their size across diverse organisms. One of the emerging paradigms of cell size homeostasis is the adder, where the cell cycle duration is established such that the cell size increase from birth to division is independent of the newborn cell size. We provide a mechanistic formulation of the adder considering that cell size follows any arbitrary non-exponential growth law. Our results show that the main requirement to obtain an adder regardless of the growth law (the time derivative of cell size) is that cell cycle regulators are produced at a rate proportional to the growth law and cell division is triggered when these molecules reach a prescribed thres

SUBMITTER: Nieto C 

PROVIDER: S-EPMC11429681 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature