Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind.

ABSTRACT: Nucleus accumbens dopamine signaling is an important neural substrate for decision-making. Dominant theories generally discretize and homogenize decision-making, when it is in fact a continuous process, with evaluation and re-evaluation components that extend beyond simple outcome prediction into consideration of past and future value. Extensive work has examined mesolimbic dopamine in the context of reward prediction error, but major gaps persist in our understanding of how dopamine regulates volitional and self-guided decision-making. Moreover, there is little consideration of individual differences in value processing that may shape how dopamine regulates decision-making. Here, using an economic foraging task in mice, we found that dopamine dynamics in the nucleus accumbens core reflect

SUBMITTER: Kocharian A 

PROVIDER: S-EPMC11429702 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature