Developmental transcriptomics in <i>Pristionchus</i> reveals the logic of a plasticity gene regulatory network.

ABSTRACT: Developmental plasticity enables the production of alternative phenotypes in response to different environmental conditions. While significant advances in understanding the ecological and evolutionary implications of plasticity have been made, understanding its genetic basis has lagged. However, a decade of genetic screens in the model nematode Pristionchus pacificus has culminated in 30 genes which affect mouth-form plasticity. We also recently reported the critical window of environmental sensitivity, and therefore have clear expectations for when differential gene expression should matter. Here, we collated previous data into a gene-regulatory network (GRN), and performed developmental transcriptomics across different environmental conditions, genetic backgrounds, and mouth-form

SUBMITTER: Reich S 

PROVIDER: S-EPMC11429705 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature