Okanin Inhibits Cell Growth and Induces Apoptosis and Pyroptosis in Oral Cancer.

ABSTRACT:

Background

Okanin, a flavonoid compound derived from Bidens pilosa L., has garnered attention for its anti-inflammatory properties. Although Bidens pilosa is commonly used in healthcare products and functional foods, the anticancer potential of okanin, particularly in oral cancer, remains underexplored. This study aims to investigate the effects of okanin on oral cancer cell lines and its potential as a therapeutic agent.

Methods

The study involved assessing the cytotoxic effects of okanin on oral cancer cell lines SAS, SCC25, HSC3, and OEC-M1. The IC50 values were determined using methylene blue assays, and the clonogenic capacity was evaluated through colony formation assays. Flow cytometry was used to analyze cell cycle progression and apoptosis. Caspase-3/7

SUBMITTER: Chia WT 

PROVIDER: S-EPMC11429813 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature