BayesAge 2.0: A Maximum Likelihood Algorithm to Predict Transcriptomic Age.

ABSTRACT: Aging is a complex biological process influenced by various factors, including genetic and environmental influences. In this study, we present BayesAge 2.0, an improved version of our maximum likelihood algorithm designed for predicting transcriptomic age (tAge) from RNA-seq data. Building on the original BayesAge framework, which was developed for epigenetic age prediction, BayesAge 2.0 integrates a Poisson distribution to model count-based gene expression data and employs LOWESS smoothing to capture non-linear gene-age relationships. BayesAge 2.0 provides significant improvements over traditional linear models, such as Elastic Net regression. Specifically, it addresses issues of age bias in predictions, with minimal age-associated bias observed in residuals. Its computational efficiency

SUBMITTER: Mboning L 

PROVIDER: S-EPMC11429879 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature