Neutral genetic diversity during selective sweeps in non-recombining populations.

ABSTRACT: Selective sweeps, resulting from the spread of beneficial, neutral, or deleterious mutations through a population, shape patterns of genetic variation at linked neutral sites. While many theoretical, computational, and statistical advances have been made in understanding the genomic signatures of selective sweeps in recombining populations, relatively less is understood in populations with little/no recombination, and arbitrary dominance and inbreeding. Using diffusion theory, we obtain the full expression for the expected site frequency spectrum (SFS) at linked neutral sites immediately post and during the fixation of moderately or strongly beneficial mutations. When a single hard sweep occurs, the SFS decays as 1/x for low derived allele frequencies ( x ), similar to the neutral SFS at e

SUBMITTER: Kaushik S 

PROVIDER: S-EPMC11429930 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature