Modulating DNA Polα Enhances Cell Reprogramming Across Species.

ABSTRACT: As a fundamental biological process, DNA replication ensures the accurate copying of genetic information. However, the impact of this process on cellular plasticity in multicellular organisms remains elusive. Here, we find that reducing the level or activity of a replication component, DNA Polymerase α (Polα), facilitates cell reprogramming in diverse stem cell systems across species. In Drosophila male and female germline stem cell lineages, reducing Polα levels using heterozygotes significantly enhances fertility of both sexes, promoting reproductivity during aging without compromising their longevity. Consistently, in C. elegans the pola heterozygous hermaphrodites exhibit increased fertility without a reduction in lifespan, suggesting that this phenomenon is conser

SUBMITTER: Ranjan R 

PROVIDER: S-EPMC11429986 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature