Serum <i>N</i>-Glycan Changes in Rats Chronically Exposed to Glyphosate-Based Herbicides.

ABSTRACT: Glyphosate, the active ingredient in many herbicides, has been widely used in agriculture since the 1970s. Despite initial beliefs in its safety for humans and animals due to the absence of the shikimate pathway, recent studies have raised concerns about its potential health effects. This study aimed to identify glycomic changes indicative of glyphosate-induced toxicity. Specifically, the study focused on profiling N-glycosylation, a protein post-translational modification increasingly recognized for its involvement in various disorders, including neurological conditions. A comprehensive analysis of rat serum N-glycomics following chronic exposure to glyphosate-based herbicides (GBH) was conducted using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results re

SUBMITTER: Adeniyi M 

PROVIDER: S-EPMC11430009 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature