Tumor-Associated Neutrophils Are a Negative Prognostic Factor in Early Luminal Breast Cancers Lacking Immunosuppressive Macrophage Recruitment.

ABSTRACT:

Background

Tumor-associated neutrophils (TANs) are important modulators of the tumor microenvironment with opposing functions that can promote and inhibit tumor progression. The prognostic role of TANs in early luminal breast cancer is unclear.

Methods

A total of 144 patients were treated for early-stage hormone-receptor-positive breast cancer as part of an Accelerated Partial Breast Irradiation (APBI) phase II trial. Resection samples from multiple locations were processed into tissue microarrays and sections thereof immunohistochemically stained for CD66b+ neutrophils. CD66b+ neutrophil density was measured separately in the stromal and intraepithelial compartment.

Results

High stromal and intraepithelial CD66b+ TAN density was a negative prognostic factor in centra

SUBMITTER: Schmidt E 

PROVIDER: S-EPMC11430230 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature