Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca²⁺]i Stability between Endoplasmic Reticulum and Mitochondria.

ABSTRACT: Fine particulate matter (PM2.5) is a significant cause of respiratory diseases and associated cellular damage. The mechanisms behind this damage have not been fully explained. This study investigated two types of cellular damage (inflammation and pyroptosis) induced by PM2.5, focusing on their relationship with two organelles (the endoplasmic reticulum and mitochondria). Animal models have demonstrated that PM2.5 induces excessive endoplasmic reticulum stress (ER stress), which is a significant cause of lung damage in rats. This was confirmed by pretreatment with an ER stress inhibitor (4-Phenylbutyric acid, 4-PBA). We found that, in vitro, the intracellular Ca²⁺ ([Ca²⁺]i) dysregulation induced by PM2.5 in rat alveolar macrophages was associated with ER stress. Change

SUBMITTER: Ma Z 

PROVIDER: S-EPMC11430257 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature