Polarized and Evanescent Guided Wave Surface-Enhanced Raman Spectroscopy of Ligand Interactions on a Plasmonic Nanoparticle Optical Chemical Bench.

ABSTRACT: This study examined applications of polarized evanescent guided wave surface-enhanced Raman spectroscopy to determine the binding and orientation of small molecules and ligand-modified nanoparticles, and the relevance of this technique to lab-on-a-chip, surface plasmon polariton and other types of field enhancement techniques relevant to Raman biosensing. A simplified tutorial on guided-wave Raman spectroscopy is provided that introduces the notion of plasmonic nanoparticle field enhancements to magnify the otherwise weak TE- and TM-polarized evanescent fields for Raman scattering on a simple plasmonic nanoparticle slab waveguide substrate. The waveguide construct is called an optical chemical bench (OCB) to emphasize its adaptability to different kinds of surface chemistries that can be e

SUBMITTER: Chen X 

PROVIDER: S-EPMC11430309 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature