Identification of TAT as a Biomarker Involved in Cell Cycle and DNA Repair in Breast Cancer.

ABSTRACT: Breast cancer (BC) is the most frequently diagnosed cancer and the primary cause of cancer-related mortality in women. Treatment of triple-negative breast cancer (TNBC) remains particularly challenging due to its resistance to chemotherapy and poor prognosis. Extensive research efforts in BC screening and therapy have improved clinical outcomes for BC patients. Therefore, identifying reliable biomarkers for TNBC is of great clinical importance. Here, we found that tyrosine aminotransferase (TAT) expression was significantly reduced in BC and strongly correlated with the poor prognosis of BC patients, which distinguished BC patients from normal individuals, indicating that TAT is a valuable biomarker for early BC diagnosis. Mechanistically, we uncovered that methylation of the TAT pr

SUBMITTER: Xie F 

PROVIDER: S-EPMC11430390 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature